Your Basket/Online Quote
Items: 0 (0,00 €)
» Search & Order
» Sign in / Register
VH1-related phosphatase
human, recombinant, E. coli
Cat. No. | Amount | Price (EUR) | Buy / Note |
---|---|---|---|
PR-350 | 20 μg | 286,30 | Add to Basket/Quote Add to Notepad |
For general laboratory use.
Shipping: shipped on dry ice
Storage Conditions: store at -80 °C
avoid freeze/thaw cycles
Shelf Life: 12 months
Accession number: NM_004090
Purity: > 90 % (SDS-PAGE)
Form: liquid (Supplied in 50 mM HEPES pH 7.4, 40 mM NaCl, 1 mM EDTA and 1 mM DTT)
Description:
The mammalian dual-specificity protein-tyrosine phosphatase VHR (for VH1-related) has been identified as a novel regulator of extracellular regulated kinases (ERKs). Vaccinia Virus VH1-related Phosphatase (VHR), also known as Dual-Specificity Phosphatase 3 (DUSP3), removes phosphate groups from tyrosine, serine, and threonine residues. It belongs to a family of phosphatases that selectively dephosphorylate MAP kinases. VHR has been shown to act as a phosphatase for several members of the MAP kinase family including ERK1, ERK2, and JNK. It is a target for the ZAP-70 kinase, and phosphorylation of VHR at tyrosine 138 leads to a downregulation of ERK2 activity. Its welldefined biochemistry has made VHR useful in screening assays for compounds that inhibit phosphatases.
BIOZ Product Citations:
Selected References:
Todd et al. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J. Biol. Chem. 274:13271.
Alonso et al. (2001) Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation. J. Biol. Chem. 276:4766.